A new weight loss drug that works better than Semaglutide? Yes, it helps you lose 25% body weight in a year
Retatrutide is a triple receptor agonist and offers hope. However, the 2023 story of anti-obesity drugs does not end there. One of the main challenges in this field is the limited efficacy of oral preparations, although Semaglutide has partially surmounted that barrier, says Dr Ambrish Mithal, Chairman of Endocrinology and Diabetes, Max Healthcare
Ever since the arrival of Semaglutide, the weight loss drug that is helping people battle both obesity and diabetes, one thought the peak had been reached — First single receptor, then dual receptor agonists. But now there’s a triple receptor agonist that can help you reduce your weight by 25 per cent in a year. This was revealed at the annual meeting of the American Diabetes Association (ADA) in San Diego, the world’s most important diabetes congress.
The quest for further improvements led scientists like German Matthias Tschop and his brilliant collaborators to develop a triple receptor agonist (GLP1, GIP and Glucagon). The one molecule that acts via three different receptors and pathways is Retatrutide. Clinical results were presented and showed that full doses of the drug produced weight loss by approximately 25 per cent in 48 weeks. There were no “non responders” as 100 per cent participants lost at least five per cent of their body weight in the same period. Something that seemed unimaginable even a few years ago has become a reality
Retatrutide is an investigational molecule suitable for once-weekly injection with the potential to treat obesity and Type 2 diabetes, according to the ADA release. The results indicate that Retatrutide has an overall safety and tolerability profile similar to other nutrient-stimulated hormone-based therapies, such as GLP-1 receptor agonists approved for obesity treatment. “It is striking that on average, participants with obesity taking the highest dose of Retatrutide lost nearly a quarter of their body weight during 11 months of treatment – on average losing nearly 60 pounds,” said Ania M. Jastreboff, MD, PhD, Associate Professor of Medicine, Director of the Yale Obesity Research Center (Y-
Weight) and co-Director of the Yale Center for Weight Management, Yale School of Medicine and lead author of the publication. “We need to treat obesity as we would any other chronic, treatable, disease with therapies that target underlying disease mechanisms. These results are an important next step in moving this new agent forward from phase 2 into phase 3 trials to assess its efficacy and safety as a potential new treatment option for patients with obesity,” she was quoted as saying.
As of my knowledge cutoff in September 2021, I'm not aware of any weight loss drug that claims to help you lose 25% of your body weight in a year or that is known to work better than Semaglutide. Semaglutide is a medication that has shown promising results for weight loss in clinical trials. It is an injectable medication that mimics the effects of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate appetite and food intake.
It's important to note that weight loss results can vary from person to person, and no single weight loss drug guarantees specific outcomes for everyone. The effectiveness of any weight loss treatment depends on various factors, including an individual's overall health, lifestyle, and adherence to the prescribed treatment plan. It's always advisable to consult with a healthcare professional for personalized advice on weight loss medications and treatments. They can provide you with the most appropriate and up-to-date information based on your specific circumstances.
If you're looking for general information about weight loss, here are a few key points:
Balanced Diet: A balanced diet that includes a variety of nutritious foods is essential for weight loss. Focus on consuming whole grains, lean proteins, fruits, vegetables, and healthy fats while limiting processed foods, sugary drinks, and high-calorie snacks.
Calorie Control: To lose weight, you generally need to consume fewer calories than your body burns. This can be achieved by tracking your calorie intake and ensuring you're in a calorie deficit. However, it's important to approach calorie restriction in a healthy and sustainable manner.
Regular Physical Activity: Engaging in regular physical activity not only burns calories but also helps improve overall fitness and health. Incorporate a combination of cardio exercises (such as jogging, cycling, or swimming) and strength training to boost metabolism and support weight loss.
Portion Control: Pay attention to portion sizes to avoid overeating. Use smaller plates and bowls, and listen to your body's hunger and fullness cues.
Hydration: Drink plenty of water throughout the day. Sometimes, thirst can be mistaken for hunger, so staying well-hydrated may help manage unnecessary snacking.
Consistency and Patience: Sustainable weight loss takes time and requires consistent effort. Focus on making long-term lifestyle changes rather than seeking quick fixes.
It's important to consult with a healthcare professional or a registered dietitian before making any significant changes to your diet or exercise routine. They can provide personalized guidance based on your specific needs and health conditions.
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